cyanheads/clinicaltrialsgov-mcp-server

bunx clinicaltrialsgov-mcp-server@latest
docker run -p 3010:3010 clinicaltrialsgov-mcp-server
git clone https://github.com/cyanheads/clinicaltrialsgov-mcp-server.git && cd clinicaltrialsgov-mcp-server && bun install

Usage

• •Point any MCP client at the public hosted instance https://clinicaltrials.caseyjhand.com/mcp
• •MCP_TRANSPORT_TYPE=http MCP_HTTP_PORT=3010 for self-hosted Streamable HTTP
• •clinicaltrials_search_studies and clinicaltrials_find_eligible for trial matching

Key features

• ✓Search studies with full-text queries, filters, pagination, sorting, and field selection
• ✓Fetch full study records, counts, field values, and field definitions
• ✓Study results extraction (outcomes, adverse events, participant flow, baselines) with summary mode
• ✓Patient-to-trial eligibility matching (clinicaltrials_find_eligible)
• ✓No API key required; public ClinicalTrials.gov REST v2
• ✓Dual transport (stdio + Streamable HTTP) and pluggable auth (none/jwt/oauth)
• ✓OpenTelemetry tracing and structured logging

Best for

Researchers, clinicians, and patients who want clinical-trial search and eligibility matching through an AI assistant

Caveats

• ⚠No authentication or API keys required — it queries the public ClinicalTrials.gov API
• ⚠Requires Bun v1.3.0+ or Node.js >= 24.0.0 for self-hosted install
• ⚠A full single study record is ~70KB, so prefer compact index results
• ⚠Rate-limited to roughly 1 request/sec with 3 retry attempts